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Cisco’s lengthy-standing perception has everyone the time been that groups should evolve to pressure forward and lead through market transitions. The equal is rectify for their government skill. Evolving their talent requires putting them in fresh roles, increasing their perspective and capacity sets and bringing fresh ideas and energy to the company. here's what we’ve these days performed with Edzard Overbeek’s fresh flood from SVP of their Asia-Pacific-Japan region to slouch of their international capabilities company and Bruce Klein’s circulate from SVP of Public Sector sales to the pinnacle of their international associate organization.
during the eventual yr, they own refocused their engineering organization for agility, more advantageous determination making, and a renewed focal point on innovation. The market participate numbers speak for themselves and their consumer self faith has by no means been enhanced. we've a powerful leadership group and the enterprise community leaders own tested powerful execution. Now the time is rectify for us to drive the next section of their organizational evolution.
With that, we're blissful to advertise Padmasree Warrior will extend her office to develop into Cisco’s Chief technology and approach Officer where she should live chargeable for settling on consumer and industry transitions and selecting Cisco’s approach to address them. Padma will drudgery intently with Cisco’s engineering, container, operations and services management, and may outline strategy, investments, acquisitions and the evolution of Cisco’s know-how companion ecosystem. additionally, Padma may live liable for conception leadership around Cisco’s products and architectures, technical capacity pile and recruiting, and she or he will raise her time with external stakeholders. The industry group CTO’s will document dotted line to Padma to allow powerful alignment between technology approach, enterprise mode and M&A pastime. during the eventual 4 years, Padma has based a major tune record of results, corresponding to constructing Cisco’s mode and execution round architectures, cloud, daily expertise approach framework, and attracting and developing industry main technical talent. They eye forward to accelerating their market position beneath Padma’s strategic course.
After 13 years of outstanding provider to Cisco, Ned Hooper should live leaving the instant Cisco family to contour an impartial funding partnership industry and to pursue his intention to live a primary investor. Ned has been engaged on his intention with us over a few months, and they appear forward to partnering with him in his fresh activity. Ned has a several ardor and capacity for funding and approach, and may center of attention on this in the subsequent section of his profession. Ned pioneered the mannequin for gigantic-scale M&A at Cisco and drove giant transactions for the enterprise corresponding to Tandberg, WebEx, Airespace, Starent and NDS. additionally, he has managed their $2B funding portfolio with each strategic and economic returns to the business. Ned’s strategy and company pile group will now document to Padma. they would want to thank Ned for his contributions, leadership, friendship and his persistent favor to at everyone times conclude the perquisite issue for Cisco.
ultimately, Pankaj Patel will assume the management of Cisco’s engineering organization. Pankaj will favor innovation, operational excellence and agile construction throughout their products, options and architectures, and continue to enhance their relevance with their expanding customer base. Pankaj’s profound client relationships and extensive engineering capabilities, combined together with his capacity to mentor and grow properly engineering capacity will serve Cisco well as they favor the subsequent section of engineering management for the business. when you could live accepted with Pankaj’s carrier company adventure, he previously spent sixteen years in the commercial enterprise area. over the eventual 13 years, Pankaj developed and grew Cisco’s carrier company industry which today money owed for about 35% of Cisco’s direct product earnings. Pankaj’s leadership in key service issuer areas corresponding to core routing, section routing, SP mobility and SP video has positioned Cisco extremely smartly for the long run. everyone the passage through his tenure Pankaj has delivered a significant number of products to the Cisco portfolio, addressing a wide array of customer needs. over the eventual 12 months because the co-leader of engineering, Pankaj has accelerated his involvement in Cisco’s commercial enterprise company, as the intersection points between service provider and commercial enterprise near closer together.
As they dwell focused on being the most fulfilling Cisco for their valued clientele, companions, buyers and personnel nowadays, they in no passage lose song of the spot they wish to ebb sooner or later. we're excited about this evolution in their corporation. gratify live a section of us in congratulating Padma, Pankaj and Ned on the next side of their respective journeys.
No outcome found, try fresh keyword!In 2011, Generex achieved the section III tribulation of its buccal birth of insulin ... I reason Generex should live would becould very well live fancy Cisco, which grew from one acquisition to the subsequent. The Ii-key peptide know-how has ...
here's A RUSH TRANSCRIPT. THIS copy may additionally now not live IN ITS remaining contour and can live updated.
this is A RUSH TRANSCRIPT. THIS replica might moreover now not live IN ITS final contour and can live up-to-date.LOU DOBBS, HOST: Tonight, President Bush puts corporate the usa on note: shape up or countenance the Justice department.
Democrats accuse the president and Republican lawmakers of being too soft on corporate abuse.
we'll own are animate reviews for you from the White condo and Capitol Hill.
WorldCom's CEO sends a epistle to the president promising cooperation and reform.
Xerox admits it made a $4-billion mistake however says, nonetheless, it isn't any WorldCom.
we'll own a several report there as neatly.
The Arizona wildfire is even better tonight. or not it's damaged through fireplace containment strains. Two further towns tonight are in jeopardy.
And former Enron personnel at the jiffy are the women of "Playboy" journal.
ANNOUNCER: here's LOU DOBBS MONEYLINE for Friday, June twenty eighth. perquisite here now Lou Dobbs.
DOBBS: respectable night.
President Bush nowadays lashed out against company misbehavior. Mr. Bush referred to groups requisite to raise the bar and never fudge their numbers. day after today, the president will exercise his radio address to induce company leaders to clear up their acts.
we now own two studies tonight. They start with Kate Snow on Capitol Hill and Senior White house Correspondent John King.
JOHN KING, CNN SENIOR WHITE residence CORRESPONDENT: neatly, Lou, the president may live speakme about this theme more and more in the days ahead. You mentioned the radio exploit the following day. The president will once again urge corporate leaders to betray accountability, double-determine their accounting practices.
Mr. Bush moreover will ebb back and forth to fresh york metropolis on July 9th, CNN is advised, and convey a speech dedicated entirely to the theme of company responsibility.
The White apartment seizing on this story, making an attempt to accumulate the initiative. Mr. Bush announcing the government is looking at what it might conclude administratively. he's urging the Congress to prefer a glance at disclosure rules as well.
Mr. Bush asserting he's concerned about this theme not only as a result of the circumstances of WorldCom and Enron, but he believes it's inflicting a slowdown in client -- a scarcity of purchaser self faith in the stock market and having an influence on the universal U.S. economy.
(begin VIDEO CLIP)
GEORGE W. BUSH, PRESIDENT OF the U.S.: corporate the united states has bought to endure in intellect there's a much better calling than making an attempt to fudge the numbers, trying to slip a thousand million here or one billion there and hope nobody notices.,
but you've got a accountability in this country to everyone the time live above board. They anticipate unreasonable requirements in their faculties, they are expecting unreasonable standards in company the usa as smartly, and i intend to implement the legislations to live confident that there are elevated specifications.
(end VIDEO CLIP)
KING: The White apartment realizing this is not just a coverage debate but additionally a political debate. Democrats making the case in this midterm election 12 months that the president and his Republican birthday party are guilty for lax law, are too restful with huge enterprise. The White apartment says Mr. Bush is determined to accumulate out forward on this one and never let Democrats execute that case.
DOBBS: John, the president calling upon Congress to behave perquisite here. The White condo has been helping Senator Phil Gramm's efforts to discontinue reform of accounting and company reform on Capitol Hill. How does this everyone rectangular off?
KING: smartly, definitely, when you consider that the Enron disclosures and now the WorldCom disclosures, the White condo is asserting that it's asking the SEC Chairman Harvey Pitt to conclude greater administratively and says it's going to propel in the Congress.
however you might live precisely usurp in that some Democrats on Capitol Hill insist there are as a minimum inconsistencies, some insist hypocrisies, within the administration's approach. everyone this now a section of a political debate in this midterm election year as well as a extremely reputable policy debate over simply precisely the spot is the role of government in telling company the us the passage to govern itself.
And, John, the president is undergoing a colonoscopy this weekend. Any word as to why he is going to live below sedation during that examination?
KING: His doctors suggested this, Lou. The mode may moreover live extremely uncomfortable. Mr. Bush has had two during the past wherein benign polyps were eliminated. His docs insist he was sedated at the remaining one.
they say, #1, sedation minimizes discomfort on the patient. And, quantity two, they are adage it makes it practicable for then the doctors to conclude a greater thorough job as a result of, if the affected person is uncomfortable, the medical doctors are likely to rush the technique.
all and sundry perquisite here at the White residence adage here is a really hobbies process for the president to try this. He has no signs in any respect. he's in wonderful health, his medical doctors say.
but he will temporarily switch power to the vp. Mr. Bush says it is a wartime precaution, anticipating Dick Cheney could live appearing president of the united states someplace within the district of one to three hours day after today.
DOBBS: ok, John. thanks very a grandiose deal.
Senior White condo Correspondent John King.
Democrats, as John reported, try to profit political abilities from these corporate scandals. nowadays, Senate Majority chief Tom Daschle referred to company corruption is threatening the fiscal system, and Daschle accused Republicans of backing policies that led to company misbehavior.
For more on the story, i am joined by passage of Kate Snow on Capitol Hill.
KATE SNOW, CNN CONGRESSIONAL CORRESPONDENT: Lou, Tom Daschle additionally said that he's heard from a lot of CEOs over the closing pair of weeks, and he stated they participate his outrage over things fancy WorldCom. He says they respect as an dreadful lot as they do, lawmakers do, that, in Daschle's words, there may live bought to live a change within the legal guidelines, the legal guidelines deserve to live reinforced.
He changed into very clear that you simply can't reserve the only guilt on the Bush administration for WorldCom's failure, but he does insist that he believes, quote, "a laissez-faire attitude during this administration has helped create the kindhearted of ambiance that exists these days."
(begin VIDEO CLIP)
SEN. TOM DASCHLE (D-SD), SENATE MAJORITY leader: there may live too a grandiose deal executive rules. there is too a proper deal govt involvement within the corporate sector. And what they want now's to eradicate government and everyone of its presence from any oversight obligations.
And, piece by piece, they dismantled the regulatory ambiance that they had and, in mammoth measure, created this sense of laissez- faire, of just total unwillingness on the a section of enforcement or regulatory corporations to play a job.
(end VIDEO CLIP)
SNOW: Now, obviously, Democrats are seizing on this concern, hoping that it might profit them some votes this tumble in the election.
whereas some Democratic strategists own observed they're now not going to live gleeful about americans dropping jobs, not at all, an additional strategist did insist to me this turned into a fortunate ruin, this WorldCom story.
condominium Democratic chief Dick Gephardt being even a microscopic more forceful, a bit more political than Tom Daschle became. He observed -- he cautioned that it was the past eight years of condo Republican exploit -- Republican exploit of the apartment of Representatives -- that has brought about one of the vital issues because they did nothing about corruption.
And, nowadays, a Republican shot back, invoking bill Clinton's legacy.
(begin VIDEO CLIP)
REP. WILLIAM THOMAS (R), CALIFORNIA: if you wish to determine a mannequin for individuals now not behaving morally -- or the style of adage it is: conclude the rectify factor even when individuals don't appear to live watching -- I suppose you will locate that the Oval workplace has a all lot more similarity to the board room than the ground of the house of Representatives.
if you're hunting for someone who set the ethical tone for the decade of the '90s, I conclude not reason you requisite to appear any farther than the previous president's habits.
(end VIDEO CLIP)
SNOW: And Republicans insist they are equally upset about what's took spot at WorldCom, they too want action, but they with ease don't observe it as a political issue, Lou.
they insist that if Democrats are going to are attempting to play up the microscopic man versus the potent during this crusade season, this operative observed, well, perhaps it will drudgery simply as smartly as it did for Al Gore.
DOBBS: everyone appropriate, Kate. One query on this. Tom Daschle, gleeful or now not, regarding the laissez-faire attitude in rolling lower back regulation. The Telecommunications Reform Act of 1996 become signed by bill Clinton. How does that...
SNOW: i am inevitable Republicans will factor to that too, and they have. They've spoke of, "appear, you can not insist that the previous eight years has been totally below Republican control. You had President Clinton within the White condo."
They've made that aspect time and again when this has near up. and that they've additionally said, you know, for a short time -- smartly, the Senate's been in exploit now for a short time of the Democrats. What about that?
DOBBS: adequate. thank you very a all lot.
Kate Snow reporting from Capitol Hill.
The parole board in California that has been due to the fact whether to liberate an infamous Manson friend who's serving lifestyles in detention center for her role in killing sprees in 1969 -- Leslie Van Houten become 19 on the time.
here is a reside photo of Leslie Van Houten. She become 19 at the time of those killings. She has faced a parole board 13 times. each and every time, she's been turned down. Her parole again has been turned down.
Let's hear in.
(begin VIDEO CLIP)
UNIDENTIFIED CALIFORNIA PAROLE BOARD MEMBER: She, although, had been arrested for auto theft. They had been no longer interestingly prosecuted. however she did own prior criminal activity in that she became a drug consumer, together with LSD, marijuana, methadrine, mescaline, and benzadrine, and this drug exercise had been happening for at least a pair of years.
(end VIDEO CLIP)
DOBBS: This, the California Parole Board, denying Leslie Van Houten, a member of the notorious Manson family unit gang, once more for a 14th time being denied a request for parole, and her being sentence continues.
"surprise" and "outrage," the words used via WorldCom's chief executive officer, John Sidgmore, in a epistle to the president these days.
Sidgmore talked about he became bowled over by passage of the invention of a $4-billion fraud at his company. He additionally outlined changes he's making in WorldCom's enterprise practices, and, among those, 17,000 layoffs that begun today.
Sidgmore additionally pledged plenary cooperation with the a number of investigations of WorldCom.
And, in the meantime, a Mississippi umpire has issued a restraining order that bars WorldCom, its auditors, and its personnel from destroying files. The select moreover stated he would appellation a computer screen to oversee doc retention. An SEC order this week simplest advised that documents live preserved.
yet another accounting scandal at Xerox. Xerox will prefer out virtually $2 billion of profits that it already suggested. An audit confirmed that Xerox posted these revenues earlier than they were in fact made.
Bruce Francis has the file.
BRUCE FRANCIS, CNN CORRESPONDENT (voice-over): Xerox admits that again in the late '90s, it robbed the longer term to execute the latest appear improved than it in fact become. The company is revising five years of outcomes.
Xerox needed to restate its financials after settling expenses with the Securities and change commission again in April and paying a $10- million satisfactory.
In a press release, CEO Anne Mulcahy said Xerox these days closes a tough chapter in the business's background. Mulcahy declined to live interviewed for their story.
score the inventory a purchase for the understanding that November, Peter Ausnit thinks that Xerox can rotate round.
PETER AUSNIT, DEUTSCHE fiscal institution SECURITIES: They observe Xerox as a corporation that can earn a substantial amount of cash over the next pair of years, peculiarly when enterprise conditions normalize.
FRANCIS: but traders, certainly folks that purchased Xerox perquisite through the late '90s, could no longer determine it so light to overlook Xerox's inaccurate accounting.
As section of its restatement, Xerox now admits it should own booked much less earnings in 1997, 'ninety eight, and '99, a time when the inventory was taking off. however the company insists that the sales -- in this case, gadget leases -- are actual and that the revenue from the late '90s really belongs in 2000, 2001, and past. for instance, 2001 finally ends up searching superior than earlier than by using half one billion dollars.
The foundation line $1.9 billion may live taken out of revenues already mentioned.
but the writer of "How organizations Lie" says conclude not carve what Xerox did.
RICHARD SCHROTH, creator, "HOW groups LIE": I don't consider it's a small, microscopic accounting mistake in any respect. companies fancy Xerox and others who own been named to the Fortune 100 greatest businesses and other such -- own a accountability to live brazenly watchful on these forms of things.
FRANCIS: neatly, former Xerox auditor KPMG maintains that they own been careful, inserting out a press release these days standing via its prior drudgery with Xerox and calling the copier business's restatement an unbelievable about-face.
Lou, they're on the fence. DOBBS: The auditor now not agreeing with the restatement.
FRANCIS: now not agreeing with the restatement, no longer agreeing with Xerox, no longer agreeing with the SEC, not agreeing with PricewaterhouseCoopers.
DOBBS: And they own now seen loads of room for disagreement, however it does execute you wonder how anybody can insist they were cautious when there may live an argument of $2 billion.
FRANCIS: elevated priced selections that cost traders some huge cash, Lou.
DOBBS: And we're, unfortunately, getting used to lots of these choices that can permeate traders some huge cash.
Bruce, thanks a all lot.
stocks closed microscopic modified on the day despite the latest scandal. today marked the conclusion of the 2nd quarter. That quarter noticed main indexes register double-digit losses.
nowadays, the Dow Jones Industrial typical fell more than 26 aspect. The Nasdaq rose pretty much 6 features. The S&P 500 dropped virtually a degree.
Jan Hopkins could own finished market coverage for us in just moments.
Tonight's MONEYLINE quick vote query is concerning the markets. we'd fancy to live sensible of: conclude you consider that this inventory market has at eventual hit backside? that you could cast your vote by means of going to cnn.com/moneyline -- cnn.com/moneyline -- and while you're there, which you can everyone the time ship us an electronic mail as well. they are going to own the outcomes of tonight's vote later in the broadcast.
We additionally want to prefer this probability to prefer a eye at your recommendations on corporate scandals. Susan Christie writes in to assert, "With Enron, Arthur Andersen, and now WorldCom, the phrase 'Figures not ever lie, however liars at everyone times figure,' became on no account extra actual."
John DePetris, "Why should al Qaeda intention greater assaults when we've Enron, WorldCom, Xerox CEOs, CFOs, et cetera, doing what the terrorists would dream of doing? it is destroying the American fiscal market."
And Brian Scott of Canada says, "Is it any question yourself that current anti-globalization protesters don't own any faith in the present capital system. everyone they observe are thieves, cheats, and liars whose best pastime is to complement themselves on the fee of traders and personnel."
we are going to own greater of your options later in the broadcast. And, as everyone the time, which you could e-mail us at email@example.com. And they at everyone times question that you simply comprise your identify and address.
Let's flip now to these wildfires raging within the western a section of the nation. a brand fresh hazard tonight in Arizona. That great hearth nearby the city of betray Low, Arizona, has broken via a containment line, threatening a nearby subdivision.
Thelma Gutierrez has greater on the narrative for us.
THELMA GUTIERREZ, CNN CORRESPONDENT: Lou, at this time, what's going on is that firefighters are working to establish a fireplace line to propel that fire again. The wind has kicked up a microscopic bit in exactly the past few minutes, which is not a superb factor obtainable.
additionally remaining nighttime, the fireplace had moved down the back aspect toward the city of Heber. Firefighters working day and night to try to dangle these hearth lines to reclaim these communities. they own got felt and that they mentioned past nowadays that, if they're able to hold those strains through the day, they'll own an excellent probability of saving the communities.
Now, nowadays and the following day, the crimson slouch and autochthonous officials own begun what they own got called van tours for residents who misplaced their buildings. The residents will most effectual own a haphazard to view their properties. as a result of safety concerns, they will not live allowed to in reality accumulate off and ebb into their property. And officers own mentioned that on account of the dainty nature of these tours, cameras aren't allowed in.
Now, to date, 419 acres of Ponderosa pines own burned up here in the betray Low enviornment, and more than 50 p.c of the land that has burned is on the Apache reservation land that has had a devastating influence on tribal individuals. up to now, they insist that two sawmills own now closed down. three hundred jobs out here could live lost. the all estimated cost of the bushes they own got lost: $237-million.
(start VIDEO CLIP)
LUCI BENALLY, APACHE TRIBE MEMBER: i am hoping that everyone and sundry is sensible of that now not best conclude americans within the demonstrate Low and Pinetop areas stand to lose their homes, however their tribe has lost so a all lot and too much. We're speakme thousands and thousands and thousands and thousands and tens of millions of bucks in an endeavor to on no account live replaced in their lifetime.
(end VIDEO CLIP)
GUTIERREZ: A spokesperson for the Apache tribe advised me a short while ago that it'll a century earlier than they're in a position to accumulate better from this fireplace, Lou.
DOBBS: Thelma, thank you very much.
Thelma Gutierrez from demonstrate Low, Arizona.
well, officers in Colorado are hoping that calmer weather will befriend their combat in opposition t wildfires. Two fires nearby Durango, Colorado, own burned more than 70,000 acres and destroyed dozens of homes. these fires are best a 3rd contained.
in the meantime, an almost a hundred and fifty,000-acre hearth near Denver may soundless live absolutely beneath manage via Sunday.
coming up tonight, the markets grappling with a surge in earnings restatements by passage of corporate the us. we'll investigate the competencies for extra surprises forward.
Wall highway, as soon as the covet of the area. Now lots of the world is questioning their mannequin of capitalism. they are going to own that record for you.
we will verify the problem that the united states faces in sustaining the battle towards terrorism and radical Islamists in their MONEYLINE "Economist" magazine string on American management, fresh directions.
And Henry Kissinger will live perquisite here to examine the us's peace efforts in the core East.
All of that and more nevertheless forward. live with us.
DOBBS: Two foremost enterprises came forward to execute grandiose restatements of their prior outcomes this week. The query nobody can reply tonight is how many more restatements are there.
Peter Viles has the story.
PETER VILES, CNN CORRESPONDENT (voice-over): As one-two punches go, this turned into an enormously expensive mixture. WorldCom, then Xerox, $6 billion worth of crummy accounting. The number of company revenue and salary restatements had already been rising, spiking an dreadful lot extra sharply in the coincident economic downturn than it did in the ultimate one.
So the query traders are asking: is this the top or just the beginning? naturally, the SEC isn't able to declare victory on bogus bookkeeping.
HOWARD SCHILIT, center FOR fiscal analysis & evaluation: The drudgery of the SEC is tower to settle upon up pace. they own anything fancy 65 existing investigations. The SEC just bought a great raise in their funds. and that i suppose the power continues to live on the SEC and different regulators to clear up the mess.
VILES: The SEC eventual nighttime took motion so one can favor CEOs to swear, beneath oath, to the accuracy of profits stories, a troublesome step meant to flush out any accounting scandals that are hiding in corporate books.
LYNN TURNER, FORMER SEC CHAIRMAN: Harvey Pitt has to slouch a step additional and say, "now not most effectual conclude I wish you to signal on the final analysis perquisite here in case you dispatch for your subsequent set of economic statements, but you requisite to recall if those discontinue up incorrect, we're going to betray round and ship you to penitentiary." VILES: that is a superb point, however Harvey Pitt has been there and spoke of that. here's what he referred to this week when asked what happens if these sworn declarations become false?
HARVEY PITT, SEC CHAIRMAN: You ebb to prison since it's fraud if you certify it and it live false.
VILES: In light of this hard talk from the SEC, there is a few hypothesis they may moreover in reality observe greater restatements within the coming weeks than they might own otherwise.
corporate the united states basically has six weeks to accumulate its books so as. Then tower in mid-August CEOs will ought to swear below oath that these books are the fact.
DOBBS: it live a opprobrium that it live near to this, but Harvey Pitt's thought perquisite here in terms of signing and swearing to those fiscal statements -- it may possibly become the solution here or a grandiose section of it.
VILES: it's a means to execute everyone say, "Come ahead. everyone those that haven't committed accounting fraud, step ahead." It turned into the president's conception initially.
DOBBS: adequate. Pete, I recognize it. thanks.
The scandals sweeping throughout corporate the usa are elevating massive questions in regards to the effectiveness of the mannequin of capitalism, its apply during this nation. international buyers, some of them, are reluctant to reserve are reserve their cash during this country, and American accounting practices are being challenged as on no account earlier than.
Kitty Pilgrim has the story.
KITTY PILGRIM, CNN CORRESPONDENT (voice-over): For years, the American company mannequin turned into touted because the most useful on earth, U.S. prevalent Accounting principles advanced, and corporate governance probably the most advanced. With debacles at Enron, ImClone, Tyco, and Adelphia dominating U.S. headlines, Europeans are starting to gloat.
"In the usa, everyone that glitters isn't gold," Deutsche bank's former CEO Rolf Breuer mentioned in a speech this week. however the usa's gadget become golden for a long time and had the numbers to betray it. Unemployment lessen than in Europe, capital markets within the U.S. outperforming Europe, bigger productivity numbers, and a stout greenback.
but now the dollar has fallen about 10 percent towards the euro up to now this yr. Markets are foundering, and the enormously touted accounting necessities being reexamined under a congressional microscope, satisfactory to execute the White apartment cover the American method.
ARI FLEISCHER, WHITE condo SPOKESMAN: The president believes that america's free commercial enterprise device is a system this is performed very well for the American people, or not it's resulted in lots comfort, or not it's resulted in a stout culture for the American americans.
PILGRIM: And a glance on the markets indicates, over the eventual two years, the Dow held up more suitable than stock indexes in Frankfurt, London, and Paris, down 28, 38, and forty two p.c respectively.
Some factor out the U.S. company mannequin is always evolving and improving from its missteps.
ROBERT SCHILLER, YALE college ECONOMIST: From decade to decade, they live trained further and further about how to Run organisations, but a section of the technique contains experimentation, and experimentation has unpredictable penalties, and some undesirable consequences, and so they are -- from one decade to the subsequent, they own to straighten out these blunders as neatly.
PILGRIM: So, during the past few months, there were changes in the passage far-off places companies are operating, and Europeans are now pushing for more unbiased board contributors and superior transparency, and the CEO incentives are moreover being reexamined. briefly, the becoming pains are being felt everyone around.
DOBBS: but nevertheless free markets and freedom. it's working.
PILGRIM: or not it's working, and...
DOBBS: a bit rough every now and then.
Kitty, thanks plenty.
nevertheless forward here, the eventual section of their collection with the "Economist" magazine. Tonight, they appear to live at the challenges dealing with the united states in sustaining the battle towards radical Islamism and terror.
Blue chips fizzle on the ultimate day of the 2d quarter. The NASDAQ ends fairly greater, however a tough quarter it become. we'll live telling you about that.
And the women of Enron parade their talents with the assist of "Playboy" journal.
All of that and greater nonetheless forward. dwell with us.
DOBBS: shares closed the 2nd quarter microscopic changed on the day despite this newest accounting information from Xerox.
Jan Hopkins has the marketplace for us now.
JAN HOPKINS, CNN CORRESPONDENT: Lou, given everyone of that, it was no longer a disagreeable displaying for shares.
The market in reality brought to yesterday's rally. but the Dow did slip into negative territory simply earlier than the closing bell when the president announced he would transfer power to the vice president perquisite through his colonoscopy tomorrow at Camp David.
For the day, the Dow become down, and it became down for the sixth week in a row. Nasdaq ended the day and week better. The S&P slipped just a little.
Christine Romans is at the fresh york stock exchange, and Greg Clarkin is on the Nasdaq.
CHRISTINE ROMANS, CNN CORRESPONDENT: well, Jan, another unstable day and two-billion shares traded today to nearby this quarter.
Xerox, as you'll predict, lost 13 p.c because of that restatement, however NIKE soared after mighty fourth-quarter earnings. Auto shares rallied today on hopes for a rebound in June motor vehicle earnings. And Philip Morris won after a horrific week. it live nonetheless down sixteen % this quarter, though. Tyco additionally gaining these days on unreasonable hopes for its CIT IPO.
however it's been a dreadful quarter for Tyco, down fifty four %. prefer a glance at AOL, parent of this community, AT&T, IBM, and GE, everyone generally held stocks, everyone struggling keen percent losses over the past three months.
Now to the NASDAQ and Greg.
GREG CLARKIN, CNN CORRESPONDENT: And, Christine, relatively tranquil day for intelligence in huge identify tech shares.
Take a eye returned on the quarter. observe how those massive cap know-how shares fared. prefer a glance at sun Microsystems down virtually forty three % for the 2d quarter. Intel down pretty much forty percent. Oracle dropping virtually 26 %. You had Cisco with a 17-percent loss. Microsoft down 8.6 percent.
but you are looking to argue steadiness? How about Dell computing device? It everyone started the quarter trading at $26.11. It ends the quarter trading at $26.14. That three-penny gain makes Dell desktop the most desirable- performing great cap technology stock for the 2nd quarter.
Jan, again to you.
Thanks, Greg. HOPKINS: The Nasdaq simply comprehensive its worst half-year on listing. it is down 25 p.c for the 12 months thus far, and that i suppose traders don't deserve to live reminded that here's the third yr in a row that the Nasdaq is reduce.
For the S&P, this is the first half-yr in 30 years, a want of 14 %.
however, Lou, a fresh quarter begins on Monday.
DOBBS: some thing to eye ahead to, as i am confident basically every person is.
smartly, accounting scandals, of path, are the center of attention this week. company misbehavior at WorldCom, Xerox dealing yet another blow to investor self belief. buyers wondering just what on the planet is occurring and what's next.
With me now within the studio is Steve Forbes, the editor of "Forbes," effect Morrison, editor of "BusinessWeek," and joining us from la, invoice O'Neil. he's the leading man at "buyers enterprise every day."
And or not it's proper to own you everyone here.
Let me begin, if i may, bill, with you. This market behaving, on the very least, badly within the countenance of Dangerous intelligence on profits and scandals. What's occurring, to your judgment?
invoice O'NEIL, "traders enterprise day by day": well, I feel that or not it's the aftermath of the massive tulip bulb craze that went on in '98 and '99. In Holland, everyone purchased tulip bulbs and they went loopy over them, and it everyone blew up. and that's what took spot in excessive-tech and biotech.
DOBBS: i used to live considering extra, invoice, about this week. They discovered concerning the tulips a very long time in the past.
O'NEIL: sure. neatly, this week, the Nasdaq has been going down on account that January 1. it live had three waves down and this closing one is a microscopic steeper, and it undercut a low. however I believe you picked up some brief selling and there's been a all lot of news. so you're doubtless in along the lows.
The market has in fact shifted to customer shares. So i am no longer so determined that these fallen leaders in the high-tech sector are absolutely elementary for a market it is slowing to regularly accumulate well over time.
DOBBS: Mark, your recommendations?
MARK MORRISON, MANAGING EDITOR, "BUSINESSWEEK": neatly, I suppose the market reacted pretty neatly on the grounds that the extent of the disagreeable information this week. The WorldCom and Xerox announcements had been rather stunning. Yet the market, after that news, acted relatively well, turned into relatively reliable.
and that i believe that in a selective means, the market did might live discipline some of the businesses that -- the spot accounting questions are nevertheless lingering, those that use...
DOBBS: Amongst people that are...
MORRISON: EBITDA, the ones which own pro forma accounting and own pushed that idea. these -- the market reacted greater in a selective manner than in a ordinary, panicky option to the news.
STEVE FORBES, EDITOR, "FORBES": I suppose it's generally right. I reason the market is attaining a bottom. I suppose the more pessimism there is, the faster this issue goes to rotate round. but one of the things I reason it really is weighing on the market, it's not the spate of scandals about companies, but a passage that possibly we're not waging this struggle on terror as vigorously as they should still. I reason if they went after Iraq and seized those oil fields, I consider you'll observe the market actually flood up.
DOBBS: it's pleasing that you'd unite those two. They did own polls this week cautioned most effectual 1/three of americans confidence that we're really successful this war. What conclude you suppose of that concept, Mark?
MORRISON: I conclude not reason it really is manner lots in the marketplace perquisite now. I consider that the market is taking possibly some solace from the incontrovertible fact that the govt and corporate the usa appear to live taking severely this mess this is been going on in bookkeeping and in governance. And that some austere reform goes to near back out of this on the different conclusion. That may additionally prefer some time, six months or a year from now. although I believe...
DOBBS: can they own time? I imply, it is the exciting query to me. invoice, let me question you to are available on this. can they truly own time? If we're drawn to restoring investor self belief, will they own time to celebrate this play out and to peer what number of more are out there?
O'NEIL: I suppose the vicissitude is, in the event you slouch through a austere correction it's extended, you should conclude something to stimulate the economic system added. or not it's extra fancy 'seventy three, '74, even a bit bit like' 29. and that i suppose that live confident you precipitate up some of these tax cuts.
They may soundless deploy a brand fresh act to give tax breaks to individuals who start a brand fresh business. That doesn't connote for everyone traders, necessarily. but let americans who birth a brand fresh enterprise simplest requisite to pay half the common tax, and the owners and founders and employees that personal stock, might live after they promote the stock over the primary 10 years, to only pay half the capital features. this would birth a huge multiply in fresh corporations.
DOBBS: i am sorry. ebb forward, invoice.
O'NEIL: I consider you want some extra stimulus since you're going to near out of this very slowly. you'll near out of it, however you're now not going to near roaring out fancy nothing ever took place.
DOBBS: Steve, your thoughts on this? greater centered investment tax credits, extra -- I can not reason about you resisting that advice.
FORBES: No, my objection could live to the targeting. Why now not simply own an throughout-the-board reduce on the capital gains tax? it truly is what they did within the mid Nineties and it worked. They mustn't overlook that the so-known as booming '90s, the primary half was the worst fiscal recovery from recession due to the fact the '20s.
DOBBS: you're fully right. it live light to overlook that. so that you'd want to observe it addressed via capital features. How in regards to the conception of a broader investment tax credit?
FORBES: smartly, I feel the key's for tax credit score, instead of attempting to play video games fancy they did in the early '60s with tax credit score on, tax credit score off. americans own received to consider here is everlasting. And relocating up, as bill suggests, the anemic tax cuts they handed ultimate summer, which are fairly small, execute these effectual now, that could uphold too.
DOBBS: well, investors and the audience of this broadcast, there's a real sense that they accumulate here, that americans want to observe actual outcomes. they're involved concerning the integrity of the markets. they may live concerned about transparency. They are looking to observe real effects from company the us.
Mark, you own been speaking about the EBITDA shares, the pro forma, in case you will, businesses and shares. real earnings -- is there going to live an enduring adjustment here, conclude you feel, to organizations that simply execute funds?
MORRISON: I feel there goes to be. and that's one explanation why I wager i'm a bit microscopic bit of a very proper information man about the WorldCom and Xerox news. I feel that this has helped propel the administration and company the usa to agree with that this become no longer only a case of a pair of disagreeable apples, but there truly is going to should live some austere apartment cleansing done.
And the option is, what? To contour of slip through this episode. and then they ebb again to industry as ordinary. And a yr from now, or two years from now, we've a worse issue.
DOBBS: We're going to recur again with bill O'Neill and effect Morrison and Steve Forbes, and argue why the surprising urgency about company reform. And we'll near to a conclusion -- or these three gents will near to a conclusion no matter if this is the failing of the Democrats or the Republicans. reside with us.
DOBBS: We're back with Steve Forbes of "Forbes" magazine and effect Morrison of "enterprise Week" and bill O'Neil of "traders company daily."
gents, as I talked about at the destroy, they wish to find out whose failing here's, Republicans or Democrats. however first, the query that we're asking their viewers tonight is, has this market bottomed? And, bill, very instantly, has this market on your judgment bottomed?
O'NEIL: I feel it doubtless has. but when it does not, I feel the government must step up and lower some taxes and conclude a few issues, as a result of there is too lots terror and it live been going on too lengthy. And they don't should own it. it's down in along what must live the backside. And there changed into best the Nasdaq this is been exerting the actual power.
MORRISON: I don't observe a bottom yet. I believe here's a undergo market and they will own to wait and spot. We're bumping along at low factor but valuations are nonetheless excessive. I don't observe a real rotate yet.
DOBBS: And, Steve, simply moments ago you used an expression, "looking for a backside." How goes the search?
FORBES: I feel if we're no longer at it, we're very nearby it. I consider traders who fancy to play timing video games should start to live going again in. I believe we're going to own a rally pretty soon. The extra pessimism there is, the more advantageous the market's going to do.
DOBBS: One would hope that they would now not observe a stronger wall of fret confront us than this, or better pessimism. Who can they guilt here? Mark, Republicans or Democrats?
MORRISON: actually politicians are partially in charge. They own been on the trip with the traders and with the accountants and with the executives. And everyone and sundry, even the media, own been on the huge journey in the late '90s, when everyone these excesses and shortcuts begun.
So, as far as Washington goes, I don't pin the guilt on either party. I consider that, absolutely, the Bush folks are having to exchange their tune very dramatically as a result of their view of letting the markets conclude everyone the law is not working.
DOBBS: looks fancy there may live an hobby in some influence other than a market result, in the case of Enron, for example. invoice?
O'NEIL: smartly, the market topped in March of 2000. so you can guilt it on either birthday party you are looking to. however human nature is human nature. and every solitary endure market I've ever seen, every solitary recession, has a few organizations ebb bankrupt, a few individuals which are doing some thing untruthful accumulate caught.
And the SEC does a proper looking respectable job. at some point they'll seize each one of these individuals. So I conclude not reason that you would live able to guilt it on one birthday celebration or the other.
DOBBS: adequate, Steve? FORBES: well, I reason if you requisite to eye on the tone of the '90s, it started perquisite at the appropriate, on the White condominium, where the perspective changed into anything goes. if you accumulate caught, spin your means out of it. The handiest component they failed to countenance up to -- they could withstand everything except temptation. So it everyone started at the true.
DOBBS: and how about Wall road, the investment bankers, the analysts, everyone of the industry banks assisting these deals?
FORBES: There became an attitude that there are not any greater rules, that you might propel the envelope, accumulate to the facet, tumble off the facet. The parachute would protect you. And effects was what counted. brief- term results is what counted. And we're having the hangover.
MORRISON: They even own to eye at where the cash turned into coming from, from a very refined group of institutional traders who Run money for states and pension funds and the rest, who own been simply very chuffed to execute investments in the Enrons of the world after they couldn't even live mindful the company or the reports.
DOBBS: bill, you accumulate the remaining live sensible on this thing. conclude you fancy the thought of everyone these refined cash managers now suing to suitable the market's correction, in case you will?
O'NEIL: smartly, I feel the largest issue, it's unhappy for the generic public. Most traders conclude not really recognize a passage to reserve money into a sound means. They conclude not truly recognize a passage to protect themselves in poorer periods. and that i'm hoping that they'll recognise this and inaugurate trying to anatomize and live trained more about the passage to select shares, how to sell them, the passage to tackle them, in preference to simply accepting what anyone else says.
DOBBS: That became possibly an usurp approach after they could watch 25 p.c profitable properties. or not it's a microscopic distinctive world, as you imply, invoice. invoice O'Neil, thanks for being with us. effect Morrison, Steve Forbes, recognize it.
coming up subsequent, difficult questions ahead for the us in the fight towards terrorists and radical Islamists. they will own the MONEYLINE "Economist" journal special document for you subsequent, in "the united states: fresh directions." dwell with us.
DOBBS: The continuing MONEYLINE "Economist" magazine collection on "American management: fresh instructions." Tonight they prefer a glance at the problem ahead for the U.S. in sustaining this fight in opposition t terrorism and radical Islamism. we're inspecting even if the usa has the will to head it on my own if integral -- politically, economically and militarily.
GEORGE W. BUSH, PRESIDENT OF the united states: nowadays, their fellow citizens, their tradition, their very freedom came below assault. DOBBS (voice-over): The president's battle on terrorism has set the stage for a fresh American period. however's moreover created challenges to the USA on two fronts: to their political and military power, and to their economic energy.
The president's coalition has been strained and tenuous from the beginning. India, Pakistan, each Important participants of that coalition, and both nuclear powers, went to the brink of conflict. France, always uniquely independent in coalition, appears more aligned from time to time with Iraq.
other European international locations, together with their closest ally, Britain, at highest attribute appear to live uneasy about U.S. coverage in the center East.
JAMES A. BAKER III, FMR. SECRETARY OF STATE: I reason as they movement forward within the battle on terrorism, which is going to live a protracted and strenuous combat, they will endure coalition fatigue. We're suffering it because of the Arab/Israeli conflict, we're struggling it as a result of the concerns between India and Pakistan.
invoice EMMOTT, EDITOR IN CHIEF, "THE ECONOMIST": I consider Colin Powell has it correct. He says that the crucial factor is to maintain talking, to betray your allies what you might live doing, why you are doing it. however now not always give them a veto about what you're doing.
BAKER: The most effectual and greatest check of a grandiose vigour is the skill to conclude whatever unilaterally when your country wide hobby requires it.
DOBBS: American leadership during this fresh era may require the USA to ebb it alone in accordance with the threats posed with the aid of both Saddam Hussein and Osama bin laden.
EMMOTT: I consider that to execute feel of Osama bin weighted down's terrorism, you should anticipate what he'd truly care to conclude is to emulate Lenin. Lenin was a terrorist who became potent because he got Russia and took over Russia. Osama bin laden is simply a terrorist presently. He can handiest accumulate effectual via getting Saudi Arabia or Pakistan or another country.
DOBBS: Kenneth Pollack is a former CIA defense favor analyst. Pollack says the time for half-measures in opposition t Saddam Hussein is handed.
KENNETH POLLACK, COUNCIL ON international family members: I feel a full- scale invasion is going to live huge. it's going to live expensive. lots of people are going to lose their lives in it. That referred to, I conclude not reason that it might live practically as expensive as fighting a warfare against Saddam Hussein once he has got nuclear weapons.
DOBBS: the area's simplest superpower, which is additionally the realm's wealthiest nation, will devoid of query live stressed by passage of the rising fees of a world battle with elusive enemies. The permeate of combating the battle this 12 months will usurp $seventy six billion.
nonetheless, if the Bush administration wins congressional approval of its total protection funds raise, that finances will nonetheless live near historic lows -- below half what it changed into everyone over the bloodless conflict, as a percent of the U.S. grievous home product.
BAKER: the district has asked lots of U.S. fiscal engine for a long time. Over the course of the past 10 years we've got been the best real supply of international boom.
UNIDENTIFIED MALE: Their heroes will now open the market.
DOBBS: america's fiscal power is the basis and engine integral to pressure this war. that is why industry scandals fancy Enron and WorldCom menace more than simply self faith in the markets and the economic system.
EMMOTT: After the bursting of the inventory market bubble and everyone of the abuses at Enron and global Crossing and Tyco, and everyone of these, I suppose america's going to own a bumpy pair of years. perquisite through that period, the usa's confidence in its capacity to proceed to fund protection spending and requisite to ebb out in the world could accumulate dented every now and then.
DOBBS: The fiscal costs and political dangers of this battle will live super. however the deserve to win the warfare is essential. And so is the possibility to obtain global peace and prosperity, in keeping with natural American values of democracy and free markets.
EMMOTT: the usa has the possibility to reshape the world in quite a lot of nice techniques in the following pair of years. The query is whether or not it'll continue to own the incentive to conclude it and consent from the relaxation of the area. My faith is that it'll own each.
DOBBS: the brand fresh edition of "The Economist" journal is committed to the altering position of yankee leadership due to the fact that September eleventh. known as "the usa's district on earth," it's on newsstands now.
And coming up next here, the results of their MONEYLINE poll on whether you suppose this market has ultimately hit bottom.
And, how the give passage of Enron has given three women the probability to benefit from company failure. remain with us.
DOBBS: And this just in to CNN. The Walt Disney company, based on Reuters, will restate its 2000 and 2001 revenue. That in line with SEC filings. The Reuters once more reporting that Disney will restate its salary. And the explanation for that restatement, in line with those SEC filings, is a math error.
Turning now to a different setting up story, explosions heard tonight in the West bank town of Hebron. Palestinian security sources insist seventy five p.c of the Palestinian complicated became destroyed. Israeli troops had been outside the complicated for a pair of days now making an attempt to negotiate the give up of Palestinians.
in the meantime, President Bush's center East intention has met with some skepticism on the G-8 acme this week. As you comprehend, G-8 leaders agreeing with the muster for Palestinian statehood. however some adage it's as much as the Palestinians to select their leaders. joining me now to argue this fresh initiative is the former Secretary of state Henry Kissinger.
Henry, first rate to own you with us perquisite here.
HENRY KISSINGER, FMR. SECRETARY OF STATE: always proper to live with you.
DOBBS: i know you were in Europe when the president reserve forward the initiative. First, what's your response? Is it a understanding behind hope?
KISSINGER: smartly, the president made clear that there is never one intention you could reserve forward for a negotiation until you own got companions for you to own some self assurance in. and i consider that was an Important contribution.
And in the next phase, once some progress is made in that route, I reason within the next section, there could live progress in negotiations. and i reason what must occur next is that the moderate Arab countries assume some accountability for the domestic adjustments that the president spelled out for the Palestinians.
since the Palestinians aren't able to conclude it via themselves below current situations. And that means, there could live created a negotiating partner.
DOBBS: Is it your sense that Saudi Arabia, in selected, Egypt, Jordan, own both the capacity and the will at the jiffy to live a positive own an effect on on any reform that the Palestinian Authority must endure to execute it feasible for statehood, even on an meantime foundation?
KISSINGER: neatly, they've the potential. and i feel they're constructing the will to conclude that. likely they'll insist that there's some growth in negotiation -- or some negotiations being conducted. earlier than the complete manner of internal trade in the Palestinian areas is completed. however I believe that they are becoming very stressed with the own an impact on on them of the continuation of suicide bombing and turmoil.
DOBBS: And for the Israelis, the president's insistence that the settlements, the construction of settlements, discontinue on the West bank and in Gaza, that there live effectively a roll-lower back to the pre-'67 warfare borders. Is that an affordable, and conclude you reason possibly productive, initiative?
KISSINGER: I suppose possibly, sure, I consider it is. I feel the president has called consideration to the incontrovertible fact that you cannot ebb from perquisite here to a closing contract. You should inaugurate through restoring circumstances by which daily being can birth once again.
And here is why he's entreated the Israelis to ebb back when the Palestinians own made their adjustments, to the situations that existed when this complete calamity everyone started. And additionally to conclusion any fresh compress undertaking. I suppose here's an inexpensive foundation on which to inaugurate negotiations.
DOBBS: Dr. Henry Kissinger, thank you very a all lot for being with us, as at everyone times.
KISSINGER: delight to live on.
DOBBS: Let's prefer a quick eye now at the effects of their MONEYLINE ballot. Tonight's query: conclude you believe that this inventory market has ultimately hit bottom? Twenty % of you said yes, 80 percent said no. And, while now not scientific, a objective indication. and that i must insist that the market doesn't issue to live arguing with the effects of this poll.
arising next, the "Dobbs document." a pair of innovations about the rising political temperature and posturing in Washington about corporate scandals. remain with us.
DOBBS: well, after the scandals at Enron, three enterprising former Enron ladies own decided to prefer handicap of their mishap through making an attempt to enrich their fortunes, performing in "Playboy" magazine. and that they're cashing in fairly neatly in a whirlwind media tour which has led them, of course, to fresh york metropolis. and they are, in case you live interested, appearing in the August situation of "Playboy" magazine.
neatly, Enron, international Crossing, Tyco, ceremony help, Qwest, Adelphia, ImClone methods, now WorldCom -- the Democrats own establish a crusade subject, company abuse. The Senate majority leader says the challenge will play in each state this November. Tom Daschle nowadays charged that the Republicans -- quote -- "dismantled the regulatory atmosphere they had and, in significant measure, created the sense of laissez faire," conclusion quote.
Even Al Gore wants to play, asserting at a fund raiser here in long island this week that the president's tax guidelines resemble the outbreak of accounting fraud.
I conclude not requisite to live a spoilsport here, however did both Mr. Gore or Senator Daschle note that these multibillion greenback company restatements ebb back to 1997? That the telecommunications act turned into 1996?
And now, of route, President Bush needs to spot them in penal involved and the treasury secretary wants to hang them excessive. George Bush and Paul O'Neill talking about company criminals, now not the Democrats. The president is siccing the Justice offshoot on the Dangerous guys and the SEC is investigating just about every most Important enterprise within the nation.
once again, I conclude not want to live a spoilsport perquisite here, however does the Bush administration neglect that it's been supporting Senator Phil Gramm's efforts to cease accounting and corporate reform on Capitol Hill for months now?
Do the Republicans and the Democrats both understand that the American investing and balloting public is sensible that or not it's been six months since Enron went bankrupt, and nobody of those condo or Senate investigations -- of which there had been a dozen -- own amounted to the repose to this element? That there were no fees introduced towards a solitary Enron executive?
If the Republicans and the Democrats are thinking about reform now, ultimately, then their movements will own to live as a minimum as energetic as their drive rhetoric.
this is MONEYLINE for this Friday night. Thanks for being with us and own a extremely pleasing weekend. For everyone here, respectable nighttime from grandiose apple.
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The authors of this study own previously reported on their taste of 30 men with metastatic CRPC treated in a single-center side II prospective tribulation of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.
In this side II trial, 50 men with PSMA-avid (defined as elevated PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after standard therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The plenary protocol can live seen below:
The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS.
75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). plenary demographic info is seen below:
These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.
In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here:
27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.
Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment.
The PFS KM curve:Patients who had a >= 50% response had a PFS of 8.3 months.
OS K-M curve seen below:Men who had a >= 50% PSA response had a median OS of 18 months.
Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were momentary G1-2 desiccate mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.
Using this expanded 50 patient cohort confirms elevated response rates and low toxicity with LuPSMA in men who had progressed after standard therapies. In patients who subsequently progressed and were administered further LuPSMA, elevated response rates were moreover observed, indicating that this treatment can live repeated with significant response. These results own provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.
Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne
Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA
Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, side 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8.
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